Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00186) | ||||||
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| BTS Name |
Thrombopoietin receptor
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| Synonyms |
TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110
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| BTS Type |
Protein
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| Family |
Type I cytokine receptor family;
Type 1 subfamily |
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| Gene Name |
MPL
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP |
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| Sequence Length |
635
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Knottin anti-c-Mpl AGTP-3 | Research | Antagonist | N.A. | Research tool | [1] | |
| Knottin anti-c-Mpl AGTP-4 | Research | Antagonist | N.A. | Research tool | [1] | |
| Knottin anti-c-Mpl AGTP-5 | Research | Antagonist | N.A. | Research tool | [1] | |
| Knottin anti-c-Mpl ETTP-2 | Research | Antagonist | N.A. | Research tool | [1] | |
| Knottin anti-c-Mpl ETTP-3 | Research | Antagonist | N.A. | Research tool | [1] | |