Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000546) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Knottin anti-c-Mpl AGTP-5
|
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| Synonyms |
Knottin AGTP-5
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Highest Status | Research | |||||
| SBP Sequence |
>Grafted peptide
GGTCLAIEGPTLRQWLCARA |
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| Template Name | AgRP | |||||
| Template Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VIII form disulfide bonds; Cys VI and Cys VII form disulfide bonds. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS042 | [1] | ||||
| Scaffold Name | Knottin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Thrombopoietin receptor | Antagonist | Research tool | N.A. | University of Jena Medical School | [1] | |