Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000547) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Knottin anti-c-Mpl ETTP-2
|
|||||
| Synonyms |
Knottin ETTP-2
|
|||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Highest Status | Research | |||||
| Template Name | EETI-II | |||||
| Template Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS042 | [1] | ||||
| Scaffold Name | Knottin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Thrombopoietin receptor | Antagonist | Research tool | N.A. | University of Jena Medical School | [1] | |