Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003584) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Diabody scDb-hERG1-beta1
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| Synonyms |
scDb-hERG1-beta1
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| Molecular Weight | 66.2 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Pichia pastoris | |||||
| Highest Status | Research | |||||
| Sequence Length | 626 | |||||
| SBP Sequence |
>Diabody scDb-hERG1-beta1
MRFPSIFTAVLFAASSALAAPVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTN NGLLFINTTIASIAAKEEGVLEKREAECADEVQLQQSGPELVKPGASVKISCKTSGYTFT EYTVHWVKQSHGKSLEWIGGINPNGGTTYNQKFKGKATLTIDKSSSSAFMELRSLTSEDS AVYYCATGWGPDYWGQGTTLTVSSAKTTPPSVYPLAPGSSDIVMTQTPTTMAASPGDKIT ITCSVSSIISSNYLHWYSQKPGFSPKLLIYRTSNLASGVPPRFSGSGSGTSYSLTIGTME AEDVATYYCQQGSDIPLTFGDGTKLDLKRADAAPTVSGGGGSGGGGSGGGGSGGGGSEVK VVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVATISSGGSYTYYPDS VKGRFTISRDKAKNTLYLQMGSLKSEDTAMYYCTRIGYDEDYAMDHWGQGTSVTVSSAKT TPPSVYSALDIVLTQSPLTLSVNIGQPASISCKSSQSLLYTNGKTYFNWLLQRPGQSPKR LIYLVSKLDSGVPDRFTGSGSGTDFTLKISRVEAEDLGVYYCAQGTHFPWTFGGGTKLEI KRADAAPTVSAAAEQKLISEEDLNGA |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | two single-chain Fragment variable (scFv) antibodies, one directed against hERG1 (scFv-hERG1from mAb-hERG1) and one against the beta1 integrin | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS031 | [1] | ||||
| Scaffold Name | Diabody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2/Integrin beta-1 | binder | Cancers [ICD-11: 2D4Z] | N.A. | University of Florence | [1] | |