Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003582)
SBP Name
Diabody anti-c-Met/PD-1 Diabody-pm
Synonyms
Diabody-pm
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System HEK293E cells
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS031
Scaffold Info
[1]
Scaffold Name Diabody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Programmed cell death protein 1
BTS Info
inhibitor Tumors [ICD-11: XH1N44] Kd: 32.48 nM Fudan University [1]
Hepatocyte growth factor receptor
BTS Info
inhibitor Tumors [ICD-11: XH1N44] Kd: 32.48 nM Fudan University [1]
References
1 Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy. Oncoimmunology. 2021 Jul 21;10(1):1914954.