Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP003520) | ||||||
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SBP Name |
Knottin anti-nAChR Ms11a-1
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Synonyms |
Knottin Ms11a-1
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Molecular Weight | 7.6 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli BL21 (DE3) | |||||
Highest Status | Research | |||||
Sequence Length | 67 | |||||
SBP Sequence |
>Knottin anti-nAChR Ms11a-1
MASKIFFFVLAVFLVMSAVLPESFAGCKKLNSNCSRQYRECCHGLVCRRPNYGNGRGILW RCVKAKK |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS042 | [1] | ||||
Scaffold Name | Knottin | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Acetylcholine receptor, alpha-1-beta-1-gamma-deltanAChRs | Inhibitor | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | IC50: 408 nM | Russian Academy of Sciences | [1] | |
Neuronal acetylcholine receptor subunit alpha-7 | Inhibitor | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | IC50: 14160 nM | Russian Academy of Sciences | [1] | |