Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00579) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Neuronal acetylcholine receptor subunit alpha-7
|
|||||
| BTS Type |
Protein
|
|||||
| Family |
ligand-gated ion channel (TC 1.A.9) family;
Acetylcholine receptor (TC 1.A.9.1) subfamily; Alpha-7/CHRNA7 sub-subfamily |
|||||
| Gene Name |
CHRNA7
|
|||||
| Organism |
Homo sapiens (Human)
|
|||||
| Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
|
|||||
| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI ICTIGILMSAPNFVEAVSKDFA |
|||||
| Sequence Length |
502
|
|||||
| Synthetic Binding Protein (SBP) Targeting This BTS |
|---|
| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Knottin anti-nAChR Ms11a-1 | Research | Inhibitor | IC50: 14160 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
| Knottin anti-nAChR Ms11a-2 | Research | Inhibitor | IC50: 14130 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
| Knottin anti-nAChR Ms11a-3 | Research | Inhibitor | IC50: 19810 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
| Knottin anti-nAChR Ms11a-4 | Research | Inhibitor | IC50: >45000 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |