Details of the BTS
General Information of Binding Target of SBP (BTS) (ID: ST00579) | ||||||
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BTS Name |
Neuronal acetylcholine receptor subunit alpha-7
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BTS Type |
Protein
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Family |
ligand-gated ion channel (TC 1.A.9) family;
Acetylcholine receptor (TC 1.A.9.1) subfamily; Alpha-7/CHRNA7 sub-subfamily |
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Gene Name |
CHRNA7
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Organism |
Homo sapiens (Human)
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Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
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UniProt ID | ||||||
UniProt Entry | ||||||
PFam | ||||||
Gene ID | ||||||
Sequence |
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI ICTIGILMSAPNFVEAVSKDFA |
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Sequence Length |
502
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Synthetic Binding Protein (SBP) Targeting This BTS |
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SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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Knottin anti-nAChR Ms11a-1 | Research | Inhibitor | IC50: 14160 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
Knottin anti-nAChR Ms11a-2 | Research | Inhibitor | IC50: 14130 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
Knottin anti-nAChR Ms11a-3 | Research | Inhibitor | IC50: 19810 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |
Knottin anti-nAChR Ms11a-4 | Research | Inhibitor | IC50: >45000 nM | Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function | [1] | |