General Information of Binding Target of SBP (BTS) (ID: ST00604)
BTS Name
Acetylcholine receptor, alpha-1-beta-1-gamma-deltanAChRs
BTS Type
Protein
Family
Alpha-1/CHRNA1 sub-subfamily;
Beta-1/CHRNB1 sub-subfamily;
Gamma/CHRNG sub-subfamily
Organism
Tetronarce californica (Pacific electric ray) (Torpedo californica)
UniProt ID
P02710, P02712, P02718, P02714
UniProt Entry
ACHA_TETCF, ACHB_TETCF, ACHD_TETCF, ACHG_TETCF
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Knottin anti-nAChR Ms11a-1 Research Inhibitor IC50: 408 nM Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function
SBP Info
[1]
Knottin anti-nAChR Ms11a-2 Research Inhibitor IC50: 1080 nM Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function
SBP Info
[1]
Knottin anti-nAChR Ms11a-3 Research Inhibitor IC50: 256 nM Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function
SBP Info
[1]
Knottin anti-nAChR Ms11a-4 Research Inhibitor IC50: 14950 nM Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function
SBP Info
[1]
References
1 Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors. Toxins (Basel). 2022 Dec 30;15(1):28.