General Information of Synthetic Binding Protein (SBP) (ID: SBP003517)
SBP Name
I-body anti-CXCR4 AD-114
Synonyms
I-body AD-114
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS040
Scaffold Info
[1]
Scaffold Name I-body
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
C-X-C chemokine receptor type 4
BTS Info
Blocker Chronic kidney disease [ICD-11: GB61] N.A. University of Sydney [1]
References
1 A single-domain i-body, AD-114, attenuates renal fibrosis through blockade of CXCR4. JCI Insight. 2022 Feb 22;7(4):e143018.