General Information of Synthetic Binding Protein (SBP) (ID: SBP003397)
SBP Name
I-body anti-CXCR4 AD-114-Im7-FH-PEG (30K)
Synonyms
I-body AD-114-Im7-FH-PEG (30K)
Molecular Weight 54.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS040
Scaffold Info
[1]
Scaffold Name I-body
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
C-X-C chemokine receptor type 4
BTS Info
Antagonist Research tool Kd: 0.7 nM The Trobe University [1]
References
1 Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4. MAbs. 2019 Oct;11(7):1331-1340.