Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003153) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Human VH dAb anti-SARS-CoV-2 clone 4D8
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| Synonyms |
Human VH dAb 4D8
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| Molecular Weight | 15 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| Sequence Length | 125 | |||||
| Template Name | Designed sdAb | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS039 | [1] | ||||
| Scaffold Name | Human VH dAb | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Spike glycoprotein | Neutralizer | SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] | Kd: 6.2 nM | Chinese Academy of Medical Sciences and Peking Union Medical College | [1] | |