General Information of Synthetic Binding Protein (SBP) (ID: SBP003010)
SBP Name
DARPin anti-EpoR 8A9
Synonyms
DARPin 8A9
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Yeast display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Erythropoietin receptor
BTS Info
Binder Hematopoiesis Kd: 2000 nM Stanford University [1]
References
1 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science. 2019 May 24;364(6442):eaav7532.