Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00120) | ||||||
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| BTS Name |
Erythropoietin receptor
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| Synonyms |
EPO-R
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| BTS Type |
Protein
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| Family |
Type I cytokine receptor family;
Type 1 subfamily |
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| Gene Name |
EPOR
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDL
VCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPL ELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRY EVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPV SLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTH KGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVG SEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGAS AASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGL SDGPYSNPYENSLIPAAEPLPPSYVACS |
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| Sequence Length |
508
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-EpoR 8A9 | Research | Binder | Kd: 2000 nM | Hematopoiesis | [1] | |
| DARPin anti-EpoR A_R3 | Research | Binder | Kd: 0.4 nM | Hematopoiesis | [1] | |
| DARPin anti-EpoR C_R3 | Research | Binder | Kd: 0.3 nM | Hematopoiesis | [1] | |
| DARPin anti-EpoR E2 | Research | Binder | Kd: 1.9 nM | Hematopoiesis | [1] | |
| DARPin anti-EpoR R11 | Research | Binder | N.A. | Hematopoiesis | [1] | |
| DARPin anti-EpoR R12 | Research | Binder | N.A. | Hematopoiesis | [1] | |
| Diabody anti-EpoR clone 330 | Research | Agonist | N.A. | Myeloproliferative neoplasm [ICD-11: XH5HH7] | [2] | |
| Diabody anti-EpoR DA10 | Research | Agonist | N.A. | Myeloproliferative neoplasm [ICD-11: XH5HH7] | [2] | |
| Diabody anti-EpoR DA5 | Research | Agonist | N.A. | Myeloproliferative neoplasm [ICD-11: XH5HH7] | [2] | |