Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001022) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Diabody anti-EpoR clone 330
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| Synonyms |
Diabody 330
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| Molecular Weight | 25.9 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| PDB ID | 4Y5Y | |||||
| Sequence Length | 247 | |||||
| SBP Sequence |
>VH Chain
HSAFAGSEVQLVESGGGLVQPGGSLRLSCAVSGFTFSKYWMTWVRQAPGKGLEWVANIKP DGSEKYYVESVKGRFTISRDNAKNSVYLQMNSVRAEDTAVYYCARVSRGGSFSDWGQGTL VTVSSGGGGS >VL Chain QSALTQPPSASGSPGQSVTISCTGTSSDVGAYNYVSWYQQHPGKAPKLMIYEVARRPSGV PDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGSNNFAVFGRGTKLTVLAAAGGG |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS031 | [1] | ||||
| Scaffold Name | Diabody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Erythropoietin receptor | Agonist | Myeloproliferative neoplasm [ICD-11: XH5HH7] | N.A. | Stanford University School of Medicine | [1] | |