Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001523)
SBP Name
Fab anti-VEGF YADS3
Synonyms
Fab YADS3
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
SBP Sequence
>Heavy Chain
EVQLVESGGGLVQPGGSLRLSCAASGFSISDYDIHWVRQAPGKGLEWVADIAPYAGATAY
ADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRSSYAYYSMDYWGQGTLVTVSSA
STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG
LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH
>Light Chain
DIQMTQSPSSLSASVGDRVTITCRASQASYYDVAWYQQKPGKAPKLLIYAASYLYSGVPS
RFSGSGSGTDFTLTISSLQPEDFATYYCQQYYYAPATFGQGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Vascular endothelial growth factor A
BTS Info
Binder Research tool Kd: 2 nM Genentech Inc [1]
Vascular endothelial growth factor A
BTS Info
Binder Research tool Kd: 3.7 nM Genentech Inc [1]
References
1 Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12467-72.