Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001490)
SBP Name	DARPin anti-APH(3)IIIa AR_3b
Synonyms	DARPin AR_3b
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli
Selection Method	Ribosome display
Highest Status	Research
Template Name	N3C

Protein Scaffold Information of This SBP
Scaffold ID	PS027 Scaffold Info					[1] , [2]
Scaffold Name	DARPin
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Aminoglycoside 3'-phosphotransferase	BTS Info	Inhibitor	Tools as biosensors and selective protein therapeutics	Kd: 0.5 nM	University of Zurich; Johns Hopkins University	[1] , [2]

References

1	Modular protein switches derived from antibody mimetic proteins. Protein Eng Des Sel. 2016 Feb;29(2):77-85.
2	Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J Biol Chem. 2005 Jul 1;280(26):24715-22.