General Information of Synthetic Binding Protein (SBP) (ID: SBP001451)
SBP Name
DARPin anti-PD-1 DARPin-1
Synonyms
DARPin-1
Molecular Weight 17.7? kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Programmed cell death protein 1
BTS Info
Blocker Ovarian cancer [ICD-11: 2C73.Z] N.A. University of Cambridge; Karolinska Institutet [1]
References
1 Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin? Proteins. J Immunol Res. 2020 Aug 4;2020:7375947.