Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001403)
SBP Name	DARPin anti-EpCAM Ec1
Synonyms	DARPin Ec1
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli BLR
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS027 Scaffold Info					[1] , [2]
Scaffold Name	DARPin
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Epithelial cell adhesion molecule	BTS Info	Binder	Ovarian cancer [ICD-11: 2C73.Z]	Kd: 0.068 nM	Radboud University; Russian Academy of Sciences	[1] , [2]

References

1	EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer. Cancers (Basel). 2020 Jul 2;12(7):1762.
2	Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1. Molecules. 2020 Oct 14;25(20):4719.