Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001014)
SBP Name	Diabody anti-CD20 cys-clone
Synonyms	GAcDb; Anti-CD20 cDb
Molecular Weight	55 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research
Template Name	Obinutuzumab

Protein Scaffold Information of This SBP
Scaffold ID	PS031 Scaffold Info					[1] , [2]
Scaffold Name	Diabody
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
B-lymphocyte antigen CD20	BTS Info	Binder	Research tool	Kd: 4 nM	University of California Los Angeles	[1] , [2]

References

1	18 F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice. Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):489-500.
2	ImmunoPET of Malignant and Normal B Cells with 89 Zr- and 124 I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Clin Cancer Res. 2017 Dec 1;23(23):7242-7252.