Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00156)
BTS Name
B-lymphocyte antigen CD20
Synonyms
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD antigen CD20
BTS Type
Protein
Family
MS4A family
Gene Name
MS4A1
Organism
Homo sapiens (Human)
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR
UniProt ID
P11836
UniProt Entry
CD20_HUMAN
PFam
PF04103
Gene ID
931
Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Sequence Length
297
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Diabody anti-CD20 cys-clone Research Binder Kd: 4 nM Research tool
SBP Info
 		[1], [2]
References
1 18 F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice. Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):489-500.
2 ImmunoPET of Malignant and Normal B Cells with 89 Zr- and 124 I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Clin Cancer Res. 2017 Dec 1;23(23):7242-7252.