Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001004) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Diabody PEG-AVP0458
|
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| Synonyms |
124I-PEG-AVP0458
|
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| Molecular Weight | 56.5? kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Highest Status | Phase I | |||||
| Template Name | Antibody CC49 | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS031 | [1] | ||||
| Scaffold Name | Diabody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Tumor-associated glycoprotein 72 | Positron-emission tomography enhancers | Ovarian cancer [ICD-11: 2C73.Z]; Prostate cancer [ICD-11: 2C82.Z] | Kd: 9.23 nM | The Trobe University; Avipep Pty Ltd | [1] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| ACTRN12612000802808 | Click to show the Detail | |||||
| Indication | TAG-72 Positive Ovarian and Prostate Cancer | |||||
| Phase | Phase I | |||||
| Title | Phase I Safety and Biodistribution Study of 124I-PEG-AVP0458 Diabody in Patients with TAG-72 Positive Ovarian and Prostate Cancer | |||||
| Status | Completed | |||||
| Sponsor | Avipep Pty Ltd | |||||