Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00378)
BTS Name	Tumor-associated glycoprotein 72
Synonyms	TAG-72
BTS Type	Protein
Organism	Homo sapiens (Human)

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Avibody ADC-AVP04	Phase I	Binder	N.A.	Multiple Adenocarcinomas [ICD-11: 2D40]	SBP Info	[1]
Diabody anti-TAG-72 AVP04-07	Research	Binder	N.A.	Tools as a valuable platform for delivery of radionuclides and other agents to tumors	SBP Info	[2]
Diabody PEG-AVP0458	Phase I	Positron-emission tomography enhancers	Kd: 9.23 nM	Ovarian cancer [ICD-11: 2C73.Z]; Prostate cancer [ICD-11: 2C82.Z]	SBP Info	[3]

References

1	Avipep. Product Development Pipeline. 2021.
2	Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET. J Nucl Med. 2010 Jul;51(7):1139-46.
3	First clinical study of a pegylated diabody 124 I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers. Theranostics. 2020 Sep 15;10(25):11404-11415.