Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001003) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Diabody anti-CD40/ERBB2
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| Synonyms |
ERBB2 CD40??HER2 ScDb
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| Molecular Weight | 56.5? kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli Rosetta (DE3) | |||||
| Highest Status | Research | |||||
| Sequence Length | 488 | |||||
| SBP Sequence |
>Diabody anti-CD40/ERBB2
VQLQQSGGGLVQPGRSLKLPCAASGFTFSDYYMAWVRQAPTKGLEWVASISYDGSSTYYR DSVKGRFTISRDNAKSTLYLQMDSLRSEDTATYYCGRHSSYFDYWGQGTTVTVSSGGGGS ADIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVP SRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVELKRATPSHNSHQVP SAGGPTANSGEVKLVESGGGLVQPGGSLRLSCATSGFNIKDTYIHWVRQAPGKGLEWVAR IYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYW GQGTTVTVSSGGGGSGGGGSDIELTQSPSTLPASLGERVTISCRASQSISNSLNWYQQKP DGTVKRLIYSTSTLESGVPSRFSGSGSGTDYSLSISSLESEDFAMYYCLQYATYPHTFGS GTKLEIKR |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS031 | [1] | ||||
| Scaffold Name | Diabody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 5 | Inhibitor | Tumors [ICD-11: XH1N44] | N.A. | Tianjin Medical University General Hospital | [1] | |
| Receptor tyrosine-protein kinase erbB-2 | Inhibitor | Tumors [ICD-11: XH1N44] | N.A. | Tianjin Medical University General Hospital | [1] | |