Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00141) | ||||||
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| BTS Name |
Tumor necrosis factor receptor superfamily member 5
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| Synonyms |
B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40
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| BTS Type |
Protein
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| Gene Name |
CD40
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for TNFSF5/CD40LG Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECL
PCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTN KTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPD DLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ |
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| Sequence Length |
277
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-FAP/CD40 MP0317 | Research | Agonist | N.A. | Tumors [ICD-11: XH1N44] | [1], [2] | |
| Diabody anti-CD40/ERBB2 | Research | Inhibitor | N.A. | Tumors [ICD-11: XH1N44] | [3] | |
| References |
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