Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001002)
SBP Name	Diabody anti-FGF2
Synonyms	ds-Diabody
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method	Phage display
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS031 Scaffold Info					[1] , [2] , [3]
Scaffold Name	Diabody
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Fibroblast growth factor 2	BTS Info	Inhibitor	Lung cancer [ICD-11: 2C25.Z]; Breast cancer [ICD-11: 2C6Z]	N.A.	Jinan University	[1] , [2] , [3]

References

1	Fine epitope mapping of a human disulphide-stabilized diabody against fibroblast growth factor-2. J Biochem. 2019 Jun 1;165(6):487-495.
2	Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer. Oncotarget. 2017 Mar 21;8(12):20187-20197.
3	Construction of a disulfide-stabilized diabody against fibroblast growth factor-2 and the inhibition activity in targeting breast cancer. Cancer Sci. 2016 Aug;107(8):1141-50.