Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00159)
BTS Name
Fibroblast growth factor 2
Synonyms
FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
BTS Type
Protein
Family
Heparin-binding growth factors family
Gene Name
Fgf2
Organism
Mus musculus (Mouse)
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).
UniProt ID
P15655
UniProt Entry
FGF2_MOUSE
PFam
PF00167
Gene ID
14173
Sequence
MAASGITSLPALPEDGGAAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVK
LQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYS
SWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Sequence Length
154
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Diabody anti-FGF2 Research Inhibitor N.A. Lung cancer [ICD-11: 2C25.Z]; Breast cancer [ICD-11: 2C6Z]
SBP Info
 		[1], [2], [3]
References
1 Fine epitope mapping of a human disulphide-stabilized diabody against fibroblast growth factor-2. J Biochem. 2019 Jun 1;165(6):487-495.
2 Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer. Oncotarget. 2017 Mar 21;8(12):20187-20197.
3 Construction of a disulfide-stabilized diabody against fibroblast growth factor-2 and the inhibition activity in targeting breast cancer. Cancer Sci. 2016 Aug;107(8):1141-50.