General Information of Synthetic Binding Protein (SBP) (ID: SBP000705)
SBP Name
VNAR anti-BAFF A07
Synonyms
VNAR A07
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Chinese hamster ovary cells
Selection Method Phage display
Highest Status Research
SBP Sequence
>CDR1
DSNCALS
>CDR3
QLPYDPLTKECILGRMDV
Protein Scaffold Information of This SBP
Scaffold ID PS065
Scaffold Info
[1]
Scaffold Name vNAR
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Tumor necrosis factor ligand superfamily member 13B
BTS Info
Inhibitor Complex autoimmune disease IC50: 58 nM Ossianix Ltd [1]
References
1 VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry. Mol Immunol. 2016 Jul;75:28-37.