Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00073) | ||||||
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| BTS Name |
Tumor necrosis factor ligand superfamily member 13B
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| Synonyms |
B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD antigen CD257
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| BTS Type |
Protein
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| Family |
Tumor necrosis factor family
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| Gene Name |
TNFSF13B
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| Organism |
Homo sapiens (Human)
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| Function |
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.; [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC
LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL |
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| Sequence Length |
285
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Avimer anti-BAFF C2 | Research | Inhibitor | N.A. | Research tool | [1] | |
| scFv anti-BAFF ABL-1 | Research | Binder | Kd: 9 nM | Research tool | [2] | |
| VNAR anti-BAFF A05 | Research | Inhibitor | IC50: 135 nM | Complex autoimmune disease | [3] | |
| VNAR anti-BAFF A07 | Research | Inhibitor | IC50: 58 nM | Complex autoimmune disease | [3] | |
| VNAR anti-BAFF A09 | Research | Inhibitor | IC50: 215 nM | Complex autoimmune disease | [3] | |
| VNAR anti-BAFF B07 | Research | Inhibitor | IC50: 60 nM | Complex autoimmune disease | [3] | |
| VNAR anti-BAFF B10 | Research | Inhibitor | IC50: 100 nM | Complex autoimmune disease | [3] | |
| References |
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