General Information of Synthetic Binding Protein (SBP) (ID: SBP000628)
SBP Name
Affitin anti-HSP110 A-C2
Synonyms
Affitin A-C2
Molecular Weight 7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Ribosome display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS007
Scaffold Info
[1]
Scaffold Name Affitin
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Heat shock protein 105 kDa
BTS Info
Inhibitor Colorectal cancer [ICD-11: 2B91.Z] Kd: 0.77 nM Label Ligue Nationale contre le Cancer and LipSTIC; Affilogic SAS [1]
References
1 Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer. Int J Cancer. 2021 Jun 15;148(12):3019-3031.