Details of the BTS
General Information of Binding Target of SBP (BTS) (ID: ST00046) | ||||||
---|---|---|---|---|---|---|
BTS Name |
Heat shock protein 105 kDa
|
|||||
Synonyms |
42 degrees C-HSP; Heat shock 110 kDa protein; Heat shock-related 100 kDa protein E7I; HSP-E7I
|
|||||
BTS Type |
Protein
|
|||||
Family |
Heat shock protein 70 family
|
|||||
Gene Name |
Hsph1
|
|||||
Organism |
Mus musculus (Mouse)
|
|||||
Function |
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities
|
|||||
UniProt ID | ||||||
UniProt Entry | ||||||
PFam | ||||||
Gene ID | ||||||
Sequence |
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA
NNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAM LLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN YGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL VEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK MNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGK DVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVF SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV KVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAG TQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVE ANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICE QEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEEL GQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPV VRTHEIRAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNIDKKEDLEGKNNLGAEAPH QNGECHPNEKGSVNMDLD |
|||||
Sequence Length |
858
|
|||||
Synthetic Binding Protein (SBP) Targeting This BTS |
---|
SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
---|---|---|---|---|---|---|
Affitin anti-HSP110 A-C2 | Research | Inhibitor | Kd: 0.77 nM | Colorectal cancer [ICD-11: 2B91.Z] | [1] | |
Affitin anti-HSP110 A-F12 | Research | Inhibitor | Kd: 1.5 nM | Colorectal cancer [ICD-11: 2B91.Z] | [1] | |
Affitin anti-HSP110 A-H3 | Research | Inhibitor | Kd: 9.3 nM | Colorectal cancer [ICD-11: 2B91.Z] | [1] | |