Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000619)
SBP Name	I-body anti-CXCR4 AD-114
Synonyms	I-body AD-114
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli; Pichia pastoris
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS040 Scaffold Info					[1] , [2]
Scaffold Name	I-body
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
C-X-C chemokine receptor type 4	BTS Info	Antagonist	Idiopathic pulmonary fibrosis [ICD-11: CB03.4]	Kd: 4.2-5.2 nM	AdAlta; La Trobe University	[1] , [2]

References

1	Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis. Sci Rep. 2018 Feb 16;8(1):3212.
2	AdAlta. Product Development Pipeline. 2021.