General Information of Synthetic Binding Protein (SBP) (ID: SBP000572)
SBP Name
Cyclotide anti-Mast cell tryptase beta MCoEETI(SDG)
Synonyms
cMCoEETI(SDG)
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 36
SBP Sequence
>Cyclotide anti-Mast cell tryptase beta MCoEETI(SDG)
ZDGGVCPKILKKCRRDSDCLAGCVCGPNGFCGSHse
Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds; cMCoEETI(SDG) is the C-to-N cyclized peptides; Hse represents homoserine; Z represents N-terminal glyoxylyl residue.
Template Name MCoEETI-II
Template Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
Protein Scaffold Information of This SBP
Scaffold ID PS023
Scaffold Info
[1]
Scaffold Name Cyclotide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Mast cell tryptase beta III
BTS Info
Inhibitor Allergic asthma [ICD-11: CA23.02]; Inflammatory disorders [ICD-11: 4A6Z] N.A. Ludwig-Maximilians-University Munich [1]
References
1 Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta. J Mol Biol. 2010 Jan 8;395(1):167-75.