Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000571) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Cyclotide anti-Mast cell tryptase beta MCoEETI(KKV)
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| Synonyms |
cMCoEETI(KKV)
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Research | |||||
| Sequence Length | 36 | |||||
| SBP Sequence |
>Cyclotide anti-Mast cell tryptase beta MCoEETI(KKV)
ZVCPKILKKCRRDSDCLAGCVCGPNGFCGAKKVHse |
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| Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds; cMCoEETI(KKV) is the C-to-N cyclized peptides; Hse represents homoserine; Z represents N-terminal glyoxylyl residue. | |||||
| Template Name | MCoEETI-II | |||||
| Template Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds. | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS023 | [1] | ||||
| Scaffold Name | Cyclotide | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Mast cell tryptase beta III | Inhibitor | Allergic asthma [ICD-11: CA23.02]; Inflammatory disorders [ICD-11: 4A6Z] | Kd: 1 nM | Ludwig-Maximilians-University Munich | [1] | |