Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000565)
SBP Name	Cyclotide anti-SET MCOG2
Synonyms	Cyclotide MCOG2
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research
Sequence Length	54
SBP Sequence	>Cyclotide anti-SET MCOG2 GGVCPKILKKCRRDSDCPGACICRGNGYCGSGSGASKAPAS[Aib]LRKL[Aib]KRLLR DA
Sequence Description	Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds; MCOG2 is the C-to-N cyclized peptides; Aib represents amino-isobutyric acid.
Template Name	MCoTI-II
Template Sequence Description	Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.

Protein Scaffold Information of This SBP
Scaffold ID	PS023 Scaffold Info					[1]
Scaffold Name	Cyclotide
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Protein SET	BTS Info	Antagonist	Chronic myeloid leukaemia [ICD-11: 2B33.2]; Acute myeloid leukaemia [ICD-11: XH8AA5]; B-cell non-hodgkin lymphoma [ICD-11: 2B33.5]	N.A.	The University of Queensland	[1]

References

1

Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer. Biochemistry. 2016 Jan 19;55(2):396-405.