General Information of Binding Target of SBP (BTS) (ID: ST00106)
BTS Name
Protein SET
Synonyms
HLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase; IGAAD; PHAPII; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I
BTS Type
Protein
Family
Nucleosome assembly protein (NAP) family
Gene Name
SET
Organism
Homo sapiens (Human)
Function
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
UniProt ID
Q01105
UniProt Entry
SET_HUMAN
PFam
PF00956
Gene ID
6418
Sequence
MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNE
QASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYL
TRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLT
KRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDD
EEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
Sequence Length
290
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Cyclotide anti-SET MCOG1 Research Antagonist N.A. Chronic myeloid leukaemia [ICD-11: 2B33.2]; Acute myeloid leukaemia [ICD-11: XH8AA5]; B-cell non-hodgkin lymphoma [ICD-11: 2B33.5]
SBP Info
[1]
Cyclotide anti-SET MCOG2 Research Antagonist N.A. Chronic myeloid leukaemia [ICD-11: 2B33.2]; Acute myeloid leukaemia [ICD-11: XH8AA5]; B-cell non-hodgkin lymphoma [ICD-11: 2B33.5]
SBP Info
[1]
References
1 Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer. Biochemistry. 2016 Jan 19;55(2):396-405.