General Information of Synthetic Binding Protein (SBP) (ID: SBP000419)
SBP Name
Kunitz domain anti-plasmin DX-1000
Synonyms
Kunitz domain DX-1000
Molecular Weight 7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Template Name LACD-D1
Protein Scaffold Information of This SBP
Scaffold ID PS043
Scaffold Info
[1]
Scaffold Name Kunitz domain
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Plasmin
BTS Info
Inhibitor Tumors [ICD-11: XH1N44] Kd: 0.099 nM Dyax [1]
References
1 PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor. Neoplasia. 2007 Nov;9(11):927-37.