Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00435)
BTS Name
Plasmin
Synonyms
pln
BTS Type
Protein
Organism
Homo sapiens (Human)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Kunitz domain anti-plasmin DX-1000 Research Inhibitor Kd: 0.099 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Kunitz domain anti-plasmin EPI-P211 Research Inhibitor N.A. Alzheimer disease [ICD-11: 8A20]
SBP Info
 		[2], [3]
Kunitz domain anti-plasmin EPI-P302 Research Inhibitor Kd: 0.087 nM Alzheimer disease [ICD-11: 8A20]
SBP Info
 		[2], [3]
References
1 PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor. Neoplasia. 2007 Nov;9(11):927-37.
2 Engineered protein scaffolds for molecular recognition. J Mol Recognit. Jul-Aug 2000;13(4):167-87.
3 Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin. Biochemistry. 1996 Jun 18;35(24):8045-57.