Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000366) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Affimer anti-Fibrinogen/Fibrin F5
|
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| Synonyms |
Affimer F5
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| Template Name | Adhiron | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS006 | [1] | ||||
| Scaffold Name | Affimer | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | One Alpha-Helix + Beta-Sheets+ Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Fibrinogen beta chain | Binder | Tools for modulating fibrinolysis, stabilizing the blood clot, and reducing bleeding complications | Kd: 52 nM | Leeds Institute for Cardiovascular and Metabolic Medicine | [1] | |
| Fibrinogen alpha chain | Binder | Tools for modulating fibrinolysis, stabilizing the blood clot, and reducing bleeding complications | Kd: 58 nM | Leeds Institute for Cardiovascular and Metabolic Medicine | [1] | |