General Information of Binding Target of SBP (BTS) (ID: ST00031)
BTS Name
Fibrinogen beta chain
BTS Type
Protein
Gene Name
FGB
Organism
Bos taurus (Bovine)
Function
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
UniProt ID
P02676
UniProt Entry
FIBB_BOVIN
PFam
PF08702 ; PF00147
Sequence
QFPTDYDEGQDDRPKVGLGARGHRPYDKKKEEAPSLRPVPPPISGGGYRARPATATVGQK
KVERKPPDADGCLHADPDLGVLCPTGCKLQDTLVRQERPIRKSIEDLRNTVDSVSRTSSS
TFQYITLLKNMWKGRQNQVQDNENVVNEYSSHLEKHQLYIDETVKNNIPTKLRVLRSILE
NLRSKIQKLESDVSTQMEYCRTPCTVTCNIPVVSGKECEKIIRNEGETSEMYLIQPEDSS
KPYRVYCDMKTEKGGWTVIQNRQDGSVDFGRKWDPYKQGFGNIATNAEGKKYCGVPGEYW
LGNDRISQLTNMGPTKLLIEMEDWKGDKVTALYEGFTVQNEANKYQLSVSKYKGTAGNAL
IEGASQLVGENRTMTIHNSMFFSTYDRDNDGWKTTDPRKQCSKEDGGGWWYNRCHAANPN
GRYYWGGAYTWDMAKHGTDDGVVWMNWQGSWYSMKKMSMKIRPYFPEQ
Sequence Length
468
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affimer anti-Fibrinogen/Fibrin F5 Research Binder Kd: 52 nM Tools for modulating fibrinolysis, stabilizing the blood clot, and reducing bleeding complications
SBP Info
[1]
Affimer anti-Fibrinogen/Fibrin G2 Research Binder Kd: 38 nM Tools for modulating fibrinolysis, stabilizing the blood clot, and reducing bleeding complications
SBP Info
[1]
pVIII-based binder anti-Fibrinogen (D/E)G(Y,F)LRP(E/D)Z mutant Research Binder N.A. Tools as alpha-helical ligands
SBP Info
[2]
pVIII-based binder anti-Fibrinogen AYLADRAD mutant Research Binder N.A. Tools as alpha-helical ligands
SBP Info
[2]
pVIII-based binder anti-Fibrinogen DSSVRFTG mutant Research Binder N.A. Tools as alpha-helical ligands
SBP Info
[2]
pVIII-based binder anti-Fibrinogen EAGPRXXP mutant Research Binder N.A. Tools as alpha-helical ligands
SBP Info
[2]
pVIII-based binder anti-Fibrinogen FDLQLLAE mutant Research Binder N.A. Tools as alpha-helical ligands
SBP Info
[2]
References
1 Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications. Blood. 2019 Mar 14;133(11):1233-1244.
2 Alpha-helically constrained phage display library. Protein Eng. 2002 Nov;15(11):943-50.