General Information of Synthetic Binding Protein (SBP) (ID: SBP000215)
SBP Name
Peptide aptamer anti-SOX2 P42
Synonyms
Peptide aptamer P42
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
SBP Sequence
>Inserted sequence
FSTLFFPLFFL
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Transcription factor SOX-2
BTS Info
Inhibitor Esophageal squamous cell carcinoma [ICD-11: 2B70.1] N.A. Xiamen University; Fujian Medical University [1]
References
1 Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma. Mol Ther. 2020 Mar 4;28(3):901-913.