Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00241)
BTS Name
Transcription factor SOX-2
BTS Type
Protein
Gene Name
Sox2
Organism
Mus musculus (Mouse)
Function
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 Binds to the proximal enhancer region of NANOG Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
UniProt ID
P48432
UniProt Entry
SOX2_MOUSE
PFam
PF00505 ; PF12336
Gene ID
20674
Sequence
MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVKRPMNAFMVWSRGQRRK
MAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKT
LMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGGGLNQRMDSYAHMNGWSNGSYSMMQEQL
GYPQHPGLNAHGAAQMQPMHRYVVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALG
SMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMAQHY
QSGPVPGTAKYGTLPLSHM
Sequence Length
319
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-SOX2 P42 Research Inhibitor N.A. Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
SBP Info
 		[1]
References
1 Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma. Mol Ther. 2020 Mar 4;28(3):901-913.