General Information of Synthetic Binding Protein (SBP) (ID: SBP000207)
SBP Name
Peptide aptamer anti-PrP clone 8
Synonyms
PA8
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
ARFEYLRDGYWVWRFT
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Major prion protein
BTS Info
Binder Prion diseases [ICD-11: 8E0Z] N.A. University of Calgary [1]
References
1 Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes -Cleavage of PrP C. Mol Neurobiol. 2018 Oct;55(10):7758-7774.