Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000193)
SBP Name
Peptide aptamer anti-VACV Apt72
Synonyms
Peptide aptamer Apt72
Molecular Weight 10-12 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Human embryonic kidney?cells 293
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
RQLVLRTR
3D Structure
Computationally Modelled Structure
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Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
DNA polymerase processivity factor component A20
BTS Info
Inhibitor Vaccinia virus infection [ICD-11: XN06N] N.A. French army Biomedical Research Institute [1] , [2]
References
1 Inhibition of vaccinia virus replication by peptide aptamers. Antiviral Res. 2009 Jun;82(3):134-40.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.