General Information of Binding Target of SBP (BTS) (ID: ST00235)
BTS Name
DNA polymerase processivity factor component A20
BTS Type
Protein
Family
Poxviruses A20 family
Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function
Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase.
UniProt ID
P68710
UniProt Entry
A20_VACCW
PFam
PF05941
Gene ID
3707671
Sequence
MTSSADLTNLKELLSLYKSLKFSDSAAIEKYNSLVEWGTSTYWKIGVQKVANVETSISDY
YDEVKNKPFNIDPGYYIFLPVYFGSVFIYSKGKNMVELGSGNSFQIPDDMRSACNKVLDS
DNGIDFLRFVLLNNRWIMEDAISKYQSPVNIFKLASEYGLNIPKYLEIEIEEDTLFDDEL
YSIIERSFDDKFPKISISYIKLGELRRQVVDFFKFSFMYIESIKVDRIGDNIFIPSVITK
SGKKILVKDVDHLIRSKVREHTFVKVKKKNTFSILYDYDGNGTETRGEVIKRIIDTIGRD
YYVNGKYFSKVGSAGLKQLTNKLDINECATVDELVDEINKSGTVKRKIKNQSAFDLSREC
LGYPEADFITLVNNMRFKIENCKVVNFNIENTNCLNNPSIETIYGNFNQFVSIFNIVTDV
KKRLFE
Sequence Length
426
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-VACV Apt72 Research Inhibitor N.A. Vaccinia virus infection [ICD-11: XN06N]
SBP Info
[1], [2]
References
1 Inhibition of vaccinia virus replication by peptide aptamers. Antiviral Res. 2009 Jun;82(3):134-40.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.