Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000187)
SBP Name
Peptide aptamer anti-HBV clone 34
Synonyms
PA34
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Huh-7 cells
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
ASLGLRPMGWRRSMCMAMLR
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Capsid protein
BTS Info
Inhibitor Hepatitis B virus infection [ICD-11: XN0GA] N.A. German Cancer Research Center [1] , [2]
References
1 Peptide aptamer-mediated inhibition of target proteins by sequestration into aggresomes. J Biol Chem. 2006 Jul 28;281(30):21345-21352.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.