General Information of Binding Target of SBP (BTS) (ID: ST00236)
BTS Name
Capsid protein
Synonyms
Core antigen; Core protein; HBcAg; p21.5
BTS Type
Protein
Family
Orthohepadnavirus core antigen family;
Orthohepadnavirus precore antigen family
Gene Name
Pre C,C
Organism
Hepatitis B virus (HBV)
Function
Encapsidates hepatitis delta genome.; May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.; Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions.
UniProt ID
Q89714
UniProt Entry
Q89714_HBV
PFam
PF08290 ; PF00906
Sequence
MQLFHLCLIISCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELLSFLPSDFFPSIRDLL
DTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNV
NMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRR
RGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
Sequence Length
212
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-HBV C1-1 Research Inhibitor N.A. Hepatitis B virus infection [ICD-11: XN0GA]
SBP Info
[1], [2]
Peptide aptamer anti-HBV clone 34 Research Inhibitor N.A. Hepatitis B virus infection [ICD-11: XN0GA]
SBP Info
[3], [2]
References
1 Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity. Oncogene. 2001 Oct 4;20(45):6579-86.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.
3 Peptide aptamer-mediated inhibition of target proteins by sequestration into aggresomes. J Biol Chem. 2006 Jul 28;281(30):21345-21352.