Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000181)
SBP Name
Peptide aptamer anti-LMO2 PA207
Synonyms
Peptide aptamer PA207
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli C41 (DE3)
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Inserted sequence
SQSRLHTILCH ECVTSFLSL
Template Name Thioredoxin (TrxA)
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Rhombotin-2
BTS Info
Binder Tools for protein function modulation Kd: 29 nM University of Cambridge [1] , [2]
References
1 Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Res. 2009 Jun 1;69(11):4784-90.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.