Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00244)
BTS Name
Rhombotin-2
Synonyms
Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2
BTS Type
Protein
Gene Name
LMO2
Organism
Homo sapiens (Human)
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
UniProt ID
P25791
UniProt Entry
RBTN2_HUMAN
PFam
PF00412
Gene ID
4005
Sequence
MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLC
GCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECF
KCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
Sequence Length
158
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-LMO2 PA207 Research Binder Kd: 29 nM Tools for protein function modulation
SBP Info
 		[1], [2]
References
1 Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Res. 2009 Jun 1;69(11):4784-90.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.