Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000168)
SBP Name
Peptide aptamer anti-ThyA pBMT101
Synonyms
Peptide aptamer pBMT101
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Yeast two-hybrid screen
Highest Status Research
SBP Sequence
>Variable region
SYLCVTPASLTEFWG
Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Thymidylate synthase
BTS Info
Inhibitor Tools for protein function modulation N.A. Harvard Medical School [1] , [2]
References
1 Isolation of peptide aptamers that inhibit intracellular processes. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2241-6.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.