Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00246) | ||||||
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| BTS Name |
Thymidylate synthase
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| Synonyms |
TS; TSase; EC 2.1.1.45
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| BTS Type |
Protein
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| Family |
Thymidylate synthase family;
Bacterial-type ThyA subfamily |
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| Gene Name |
thyA
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| Organism |
Escherichia coli (strain K12)
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| Function |
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF DYRFEDFEIEGYDPHPGIKAPVAI |
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| Sequence Length |
264
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Peptide aptamer anti-ThyA pBMT101 | Research | Inhibitor | N.A. | Tools for protein function modulation | [1], [2] | |
| Peptide aptamer anti-ThyA pBMT101A | Research | Inhibitor | N.A. | Tools for protein function modulation | [1], [2] | |
| Peptide aptamer anti-ThyA pBMT101Q | Research | Inhibitor | N.A. | Tools for protein function modulation | [1], [2] | |
| Peptide aptamer anti-ThyA pBMT101S | Research | Inhibitor | N.A. | Tools for protein function modulation | [1], [2] | |